![]() ![]() These effects were associated with a blockage of CCAAT-enhancer-binding protein-α and peroxisome proliferator-activated receptor-γ 2 mRNA expression. Hence, on the one hand, trans-10, cis-12 inhibited uncoupling protein (UCP) 1 induction by norepinephrine (NE) and produced a decrease in leptin mRNA levels. Our aim was to characterize the separate effects of both CLA isomers on thermogenic capacity in cultured brown adipocytes. Most of them use mixtures containing several CLA isomers, mainly cis-9, trans-11 and trans-10, cis-12 in equal concentration. Previous studies have shown that brown adipose tissue (BAT) is particularly sensitive to CLA-supplemented diet feeding. Conjugated linoleic acid (CLA) is reported to have health benefits, including reduction of body fat. ![]()
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